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Journal of Chemical and Pharmaceutical Research
A simple, rapid and prcise method was developed for the simultaneous determination of Amlodipine Besylate (AML) and Hydrochlorothiazide (HTZ) in tablet dosage form. Analysis was performed on a C8 (250 mm x 4.6 mm, 5 µm) column with acetonitrile:0.5 M phosphate buffer (pH 3) 60:40 (v/v) as mobile phase, a flow rate 1.0 ml/min and column temperature 30ºC. Quantitation was achieved with UV detection at 272 nm. Both the drugs were well resolved on the stationary phase and the retention times werefatcat:mllwmvtlsvdizcewlz4qi2ppma