Prognostic factors in follicular lymphoma: new tools to personalize risk

C. Casulo
2016 Hematology ASH Education Program  
Follicular lymphoma (FL) is the most common indolent lymphoma, and it has a long median overall survival (OS). However, the recent discovery of clinical and biological prognostic biomarkers in FL is shedding light on FL heterogeneity and the need for a precise and risk-stratified individual approach at diagnosis and relapse. Many FL patients who are asymptomatic with indolent disease can be vulnerable to the toxicity, emotional distress, and financial burden of overtreatment. Yet a subset of FL
more » ... patients develop chemoresistance to standard chemoimmunotherapy, experience transformation to aggressive lymphoma and rapid progression, and represent the population most in need of novel therapies and curative approaches. Novel biomarkers that incorporate both clinical and genetic determinants of poor risk are being developed with the hope of identifying high-risk patients at diagnosis in order to offer biologically rational targeted therapies. Learning Objectives • To review clinical prognostic indices in FL and learn about novel prognostic markers predicting poor risk • To understand how prognostic markers in FL help predict heterogeneity and how this may shape our approach to patients
doi:10.1182/asheducation-2016.1.269 pmid:27913491 fatcat:ln5z5nyrsbfmbmo2dw4qpx5joa