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Elevation in Tanis Expression Alters Glucose Metabolism and Insulin Sensitivity in H4IIE Cells
2003
Diabetes
Increased hepatic glucose output and decreased glucose utilization are implicated in the development of type 2 diabetes. We previously reported that the expression of a novel gene, Tanis, was upregulated in the liver during fasting in the obese/diabetic animal model Psammomys obesus. Here, we have further studied the protein and its function. Cell fractionation indicated that Tanis was localized in the plasma membrane and microsomes but not in the nucleus, mitochondria, or soluble protein
doi:10.2337/diabetes.52.4.929
pmid:12663463
fatcat:6schh4a7zvdjnolkidzgq67whq