A review has been made of the immunological system, especially on the relationship among T-cells, catecholamine (hereinafter called CA) and the duration of psycho-social stress. The subjects were 42 patients with complaints regarded as psychologenic, namery, 24 cases of tongue pain, 5 cases psychogenic temporomandibular joints syndrome, 4 cases of psychogenic dry mouth, 3 cases each of tooth and gum pain, 3 cases of relapsed aphthous stomatitis. Their age ranged from 16 to 76 with and average

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... .3. CA was measured for the mean and tasts for immunity functions were made on T-cells, B-cells, helper-T cells, and suppressor-T cells. Test were entrusted to SRL Inc. The patients were classified into those with a CD 4/8 ratio of less than 2.0 (hereinafter called the low CD 4/8 ratio group) and those with a CD 4/8 ratio over 2.0 (hereinafter called the high CD 4/8 ratio group) A decrease of CD4 was observed in the low CD 4/8 ratio group, and a decrease of CD8 in high CD 4/8 ratio group. The period during which outpatients exprienced stress was judged to be 18.8 months for the low CD 4/8 ratio group, compared with only 12.3 months for the high CD 4/8 ratio group. A higher value of noradrenaline as CA was observed in the low CD 4/8 raito group.