Objective: To evaluate the efficacy and factors of prednisone combined with cyclophosphamide (CTX) treatment of primary immunoglobulin A (IgA). Methods: Ninty six cases of IgA nephropathy patients were treated with prednisone combined CTX from January 2013 to December 2014. Renal function before and after treatment was measured and the effects of prednisone combined CTX in patients with IgA nephropathy were analyzed. Results: Thirty eight cases were cured in 96 cases of IgA nephropathy patients

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... (39.58%), 42 cases were effective (43.75%), 16 cases were ineffective (16.67%), totally, and 80 were was ffective (83.33%). After treatment, blood urea nitrogen (BUN), serum creatinine (blood Scr), 24 h urine protein (24 h Uab) were lower than before treatment, and endogenous creatinine clearance (Ccr) were significantly higher than before treatment (P<0.05). After logistic regression, 24 h urine protein levels, Ccr before treatment, LEE kidney tissue classification, hypertension were risk factors of prednisone combined with CTX treatment on prognosis of patients with IgA nephropathy. Conclusions: Prednisone combined CTX is effective in the treatment of IgA nephropathy, but clinical and pathological features of patients should be considered in the choice of the program.