Biological activity studies on some transition metal complexes containing thiazole moiety. Microwave synthesis, spectral, thermal characterization and computational modeling

Rajendra Jain, D Mishra, A Mishra
2011 Der Pharma Chemica   unpublished
voltammetry, electrical conductivity and XRD analysis. The complexes exhibit coordination number 4 or 6. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal: ligand) ratio. IR data shows that the ligand coordinates with the metal ions in a bidentate manner through the phenolic oxygen and azomethine nitrogen. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behavior of metal complexes shows that the
more » ... rated complexes lose water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. The Schiff base and metal complexes show a good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.