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Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
2006
BMC Bioinformatics
Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cells. Transcription factors constitute a class of the regulatory molecules that typically require posttranscriptional modifications or ligand binding in order to exert their function. Therefore, such important functional changes of transcription factors are not directly visible in the microarray experiments. Results: We developed a novel
doi:10.1186/1471-2105-7-s2-s13
pmid:17118134
pmcid:PMC1683568
fatcat:zdusg6vf2jhqzcknrr3cletlwy