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IcmQ in the Type 4b Secretion System Contains an NAD+ Binding Domain
2013
Structure
A Type 4b secretion system (T4bSS) is required for Legionella growth in alveolar macrophages. IcmQ associates with IcmR, binds to membranes, and has a critical role in the T4bSS. We have now solved a crystal structure of IcmR-IcmQ to further our understanding of this complex. This structure revealed an amphipathic four-helix bundle, formed by IcmR and the N-terminal domain of IcmQ, which is linked to a novel C-terminal domain of IcmQ (Qc) by a linker helix. The Qc domain has structural homology
doi:10.1016/j.str.2013.05.017
pmid:23850453
pmcid:PMC3816012
fatcat:uzrv3ecjobaetjnh6qrftiiw6a