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ABSTRACTPurposeThermodynamic analysis of protein structure in silico has been shown to be effective in discriminating between the effects of benign and pathogenic variation in the MSH2 protein. The aim of this study was to determine whether similar analysis of variants in MEN1 could help assess the impact of novel missense variants in the setting of a diagnostic laboratory.Methods338 previously-reported missense variants in MEN1 were analysed for their predicted effects on thermodynamicdoi:10.1101/661512 fatcat:r5n7ahlmpfab5leluyzscnsipu