Non-coding yet non-trivial: a review on the computational genomics of lincRNAs

Travers Ching, Jayson Masaki, Jason Weirather, Lana X. Garmire
2015 BioData Mining  
Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known
more » ... nisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.
doi:10.1186/s13040-015-0075-z pmid:26697116 pmcid:PMC4687140 fatcat:6adlfaqsuzblri4w66mqrdl6rq