Total Synthesis of cis,cis-Ceratospongamide, a Bioactive Thiazole-Containing Cyclic Peptide from Marine Origin

Fumiaki Yokokawa, Hirofumi Sameshima, Takayuki Shioiri
2001 Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry  
The first total synthesis of cis,cis-ceratospongamide (1a), isolated from marine source, was accomplished via thiazole synthesis using CMD methodology, DEPC-mediated peptide coupling, macrolactamization, and cyclodehydration. Comparison of the cyclization sites and coupling reagents in the macrolactamization step was also investigated.
doi:10.1055/s-2001-14641 fatcat:pq56trfovnhvho4gby5kwdk4zi