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Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells
Objective: The threonine/serine kinase glycogen synthase kinase 3 (GSK-3) targets multiple substrates in T-cells, regulating the expression of Tbet and PD-1 on Tcells. However, it has been unclear whether GSK-3 can affect the motility of T-cells and their interactions with antigen presenting cells. Results: Here, we show that GSK-3 can regulate T-cell motility. Inhibition of GSK-3, by small molecule SB415286, reduced T-cell motility in terms of distance and displacement. Although SB415286doi:10.21203/rs.2.15302/v1 fatcat:zgvx7o3aofbgllaf3tmkpbtyty