Antimicrobial, cytotoxic and antioxidant activity of methanolic extract of Glycyrrhiza glabra

Shapna Sultana, Afroza Haque, Kaiser Hamid, Kaniz Urmi, Sumon Roy
2010 Agriculture and Biology Journal of North America  
The present study was undertaken to explore the free radical scavenging, antimicrobial and cytotoxic activity of the methanolic extract of Glycyrrhiza glabra (Fabaceae) using DPPH, disc diffusion and brine shrimp lethality bioassay methods respectively. Different degrees of effect was noticed incase of different methods of study. In antimicrobial screening, G. glabra showed potent antimicrobial activity against almost all the test organisms except Pseudomonas aeruginosa. It exhibited highest
more » ... sitivity against Staphylococcus aureus with the zone of inhibition 22 mm. The extract possessed potent cytotoxic activity having LC 50 value of 0.771µg/ml. On the other hand, the free radical scavenging activity was found moderate having IC 50 value of 87.152 µg/ml.
doi:10.5251/abjna.2010.1.5.957.960 fatcat:ukfgcdyosjf3pmit7hm5trqysa