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Curcumin, a polyphenol found in the rhizomes of Curcuma longa, improves obesityassociated inflammation and diabetes in obese mice. Curcumin also suppresses adipocyte differentiation, although the underlying mechanism remains unclear. Here, we used 3T3-L1 cells to investigate the details of the mechanism underlying the anti-adipogenic effects of curcumin. Curcumin inhibited mitogen-activated protein kinase (MAPK) (ERK, JNK, and p38) phosphorylation that was associated with differentiation ofdoi:10.1152/ajpcell.00369.2009 pmid:20357182 fatcat:g7mbgtr3cvf6bjwea56iq5mjnm