Translational Bioinformatics for Diagnostic and Prognostic Prediction of Prostate Cancer in the Next-Generation Sequencing Era

Jiajia Chen, Daqing Zhang, Wenying Yan, Dongrong Yang, Bairong Shen
2013 BioMed Research International  
The discovery of prostate cancer biomarkers has been boosted by the advent of next-generation sequencing (NGS) technologies. Nevertheless, many challenges still exist in exploiting the flood of sequence data and translating them into routine diagnostics and prognosis of prostate cancer. Here we review the recent developments in prostate cancer biomarkers by high throughput sequencing technologies. We highlight some fundamental issues of translational bioinformatics and the potential use of
more » ... computing in NGS data processing for the improvement of prostate cancer treatment.
doi:10.1155/2013/901578 pmid:23957008 pmcid:PMC3727129 fatcat:wmsiqvou6vbqph5wox5sapgele