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DPYD genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from Slovakia
2017
General Physiology and Biophysics
Dihydropyrimidine dehydrogenase (DPD) acts as the first-step enzyme catabolizing pyrimidines in vivo. DPYD gene mutations interfere with the breakdown of uracil and thymine. Genetic variations of DPYD can cause an enzyme deficiency state, which results in severe toxicity or other adverse side effects such as DNA damage or RNA damage caused by imbalance of the nucleotide pool. Our case-control study investigates the possible association between seven DPYD gene polymophisms (rs1801267,
doi:10.4149/gpb_2017046
pmid:29372689
fatcat:btiyxkhjnzcptbkdadu6lzk7bi