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MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium
[article]
2022
bioRxiv
pre-print
Airway mucus acts as a protective barrier and vehicle for clearance of pathogens, providing the lungs with a defense mechanism called mucociliary clearance (MCC). Airway mucus is composed of two mucins, mucin 5B (MUC5B) and 5AC (MUC5AC) that form a hydrogel that enables functional clearance in health. However, abnormalities in mucin expression, specifically increases in MUC5AC is observed in chronic respiratory diseases and leading to defective MCC. Our current understanding of MCC impairment
doi:10.1101/2022.03.11.484020
fatcat:5ihwnkeonjb3didvemfubo4wie