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SPLATCHE3 simulates genetic data under a variety of spatially explicit evolutionary scenarios, extending previous versions of the framework. The new capabilities include long-distance migration, spatially and temporally heterogeneous short-scale migrations, alternative hybridization models, simulation of serial samples of genetic data and a large variety of DNA mutation models. These implementations have been applied independently to various studies, but grouped together in the current version.doi:10.1093/bioinformatics/btz311 pmid:31077292 pmcid:PMC6821363 fatcat:4h6yyfdodvazvdndu653idfb3m