Coumarin-Chalcone Hybrids as new scaffolds in drug discovery

Saleta Vázquez Rodríguez, Eugenio Uriarte, Lourdes Santana, Silvia Serra
2009 Proceedings of The 13th International Electronic Conference on Synthetic Organic Chemistry   unpublished
The first hydroxilated series of coumarin-chalcone derivatives has been synthesize starting from the corresponding salicyl aldehyde and β-ketoester precursors by a Knoevenagel reaction in order to obtain the methoxy derivatives which have been further hydrolyzed with a Lewis acid.
doi:10.3390/ecsoc-13-00191 fatcat:h5nwghlzyzfihpfszlwoqlzemy