This study aimed to determine the ability of the C-reactive protein (CRP)-to-albumin ratio (CAR) to predict short-term mortality in patients with COVID-19. Material and methods: This retrospective, observational, cohort study included patients with COVID-19. The patients' demographics, clinical characteristics, CRP, albumin, CAR, blood urea nitrogen, creatinine, highsensitive cardiac troponin I and all-cause mortality within 30 days after admission were noted. The receiver operating

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... ic curve analysis was performed, and odds ratios (OR) were calculated to determine the discriminative ability of the parameters. Results: A total of 103 patients with a median of age of 57 (25th -75th percentiles: 32-76) years were included in the study. The rate of 30-day mortality was 4.8% for the study cohort. According to the best Youden's index, the cutoff value for CRP was determined as 66.67 (sensitivity: 80%, specificity: 78.6%), and the area under curve (AUC) value was 0.801 (95% confidence interval [CI]: 71.1-87.3). According to the best Youden's index, the cut-off value for CAR was 0.18 (sensitivity: 80%, specificity: 78.6%), and the AUC value was 0.806 (95% CI: 71.6-87.7). There was no statistically significant difference between the AUC values of CRP and CAR (DeLong equality test, p=0.938). The OR of CRP (>66.67 mg/L) and CAR (>0.18) for 30-day mortality were 14.667 (95% CI: 1.555-138.299) and 13.818 (95% CI: 1.468-130.076), respectively. Conclusion: CAR was not useful in predicting 30-day mortality in patients with COVID-19. The calculation of CAR rather than CRP had no clinically significant contribution to the prediction of 30-day mortality in this patient group.