Preclinical Performance Evaluation of Percutaneous Glucose Biosensors

Robert J. Soto, Mark H. Schoenfisch
2015 Journal of Diabetes Science and Technology  
The utility of continuous glucose monitoring devices remains limited by an obstinate foreign body response (FBR) that degrades the analytical performance of the in vivo sensor. A number of novel materials that resist or delay the FBR have been proposed as outer, tissue-contacting glucose sensor membranes as a strategy to improve sensor accuracy. Traditionally, researchers have examined the ability of a material to minimize the host response by assessing adsorbed cell morphology and tissue
more » ... ogy. However, these techniques do not adequately predict in vivo glucose sensor function, necessitating sensor performance evaluation in a relevant animal model prior to human testing. Herein, the effects of critical experimental parameters, including the animal model and data processing methods, on the reliability and usefulness of preclinical sensor performance data are considered. Keywords animal model, biocompatibility, blood glucose, blood glucose meter, foreign body response, in vivo glucose sensor
doi:10.1177/1932296815590628 pmid:26085566 pmcid:PMC4667323 fatcat:7pbusyfatbd5tgvqv3amkuz34u