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After hormonal ablation, 90% of the secretory epithelial cells of the prostate undergo apoptosis, and the remaining cells are reorganized as the tissue is remodeled. Using differential display RT-PCR of total RNA extracted from the rat ventral prostate before and 4 days after castration, we have cloned and sequenced a number of complementary DNAs whose cognate messenger RNAs (mRNAs) may be either up-or down-regulated during prostatic regression. One sequence of particular interest, 25.2, isdoi:10.1210/en.140.7.3328 pmid:10385430 fatcat:bxfengrkzve6zpzifcjoemfati