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The serotonin 1A (5-HT 1A ) receptor is an important member of the superfamily of seven transmembrane domain G-proteincoupled receptors. We have examined the modulatory role of cholesterol on the ligand binding of the bovine hippocampal 5-HT 1A receptor by cholesterol complexation in native membranes using digitonin. Complexation of cholesterol from bovine hippocampal membranes using digitonin results in a concentration-dependent reduction in specific binding of the agonist 8-OH-DPAT anddoi:10.1080/09687860500093453 pmid:16096266 fatcat:5y3zjc4rebfoporqj5mh23ahju