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Extrachromosomal circular DNA elements (eccDNAs) have been described in the literature for several decades, and are known for their broad existence across different species1,2. However, their biogenesis and functions are largely unknown. By developing a new circular DNA enrichment method, here we purified and sequenced full-length eccDNAs with Nanopore sequencing. We found that eccDNAs map across the entire genome in a close to random manner, suggesting a biogenesis mechanism of random ligationdoi:10.1038/s41586-021-04009-w pmid:34671165 pmcid:PMC9295135 fatcat:cjj53gc3yfcqddwmr5nvdofg2a