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A Trypanosoma cruzi Antigen and Epitope Atlas: deep characterization of antibody specificities in Chagas Disease patients across the Americas
During an infection, the immune system produces pathogen-specific antibodies. With time, these antibody repertoires become specific to the history of infections and represent a rich source of diagnostic markers. However, the specificities of these antibodies are mostly unknown. Here, using high-density peptide arrays we examined the specificities of human antibody repertoires of Chagas disease patients. Chagas disease is a neglected disease caused by Trypanosoma cruzi, a protozoan parasite thatdoi:10.1101/2022.08.19.504544 fatcat:ykgqr3k7j5ebtlyw6q6xcnj674