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Intoduction. Multiple myeloma (MM) and chronic myelogenous leukaemia (CML) are two haematological malignancies developing through tumour transformation of lymphoid and myeloid progenitor cells, respectively, not sharing a common ancestry. Coexistence of the two diseases is extremely rare.Aim. Clinical description of a patient diagnosed with CML in a few months after start of MM therapy.Main findings. We report a clinical case of MM and CML in a 62 years-old female patient. MM was diagnoseddoi:10.35754/0234-5730-2020-65-4-501-513 fatcat:525rk2rvkfebroitkj5h754n3q