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Clinical case of effective treatment of gestational pemphigoid with intravenous immunoglobulins
Клінічний випадок успішного лікування внутрішньовенними імуноглобулінами пемфігоїда у вагітних

V.S. Yavir, Bogomolets National Medical University, Kyiv, Ukraine, K.O. Spichak, V.О. Berestovoy, A.M. Martych, I.V. Sokol, M.B Liashko, D.O. Govsieiev, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine (+9 others)
2020 Ukrainian journal of Perinatology and Pediatrics  

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Gestational pemphigus — is a rare autoimmune condition that manifest during pregnancy. This pathology was described for the first time in 1827 by the Karl Martius, but until now remains insufficiently studied and as a result, difficulties arise in the differential diagnosis and treatment. Clinical manifestations of the disease characterized by the appearance of a polymorphic rash on the skin and mucous membranes. In patients with impaired immune tolerance pemphigus can be complicated by
more » ... ivation of the immune system. To date, pregnancy is not considered as a factor that can aggravate the course of pemphigus, since during pregnancy the disease can worsen, enter into complete remission, or remain unchanged. In the literature, there is information about the manifestation of pemphigus in puerperium after rapid decrease of corticosteroid hormones in serum. The clinical course of gestational pemphigus is variable and can lead to diagnostic failures. The diagnosis usually made according to the clinic, histopathology and laboratory findings. In this case report we describe a case of diagnosis and treatment of gestational pemphigoid, refractory to corticosteroid therapy. Clinical improvement and recovery achieved after a course of high doses of intravenous immunoglobulins. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: pemphigoid, pregnancy, autoimmune disease, intravenous immunoglobulin.
doi:10.15574/pp.2020.83.87 fatcat:aukqnjh5mzhcvioe2wdwqll7bu
DOAJ
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V.S. Yavir, Bogomolets National Medical University, Kyiv, Ukraine, K.O. Spichak, V.О. Berestovoy, A.M. Martych, I.V. Sokol, M.B Liashko, D.O. Govsieiev, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine, Bogomolets National Medical University, Kyiv, Ukraine, Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine. "Clinical case of effective treatment of gestational pemphigoid with intravenous immunoglobulins." Ukrainian journal of Perinatology and Pediatrics (2020) 87-91