New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data

Xin Shao, Xiaoyan Lu, Jie Liao, Huajun Chen, Xiaohui Fan
2020 Protein & Cell  
For multicellular organisms, cell-cell communication is essential to numerous biological processes. Drawing upon the latest development of single-cell RNA-sequencing (scRNA-seq), high-resolution transcriptomic data have deepened our understanding of cellular phenotype heterogeneity and composition of complex tissues, which enables systematic cell-cell communication studies at a single-cell level. We first summarize a common workflow of cell-cell communication study using scRNA-seq data, which
more » ... ten includes data preparation, construction of communication networks, and result validation. Two common strategies taken to uncover cell-cell communications are reviewed, e.g., physically vicinal structure-based and ligand-receptor interaction-based one. To conclude, challenges and current applications of cell-cell communication studies at a single-cell resolution are discussed in details and future perspectives are proposed.
doi:10.1007/s13238-020-00727-5 pmid:32435978 fatcat:gu7rpbzxfbeujeplsaqtx35eni