Mast cell changes in experimental diabetes: focus on attenuation of allergic events

Vinicius F Carvalho, Emiliano O Barreto, Renato SB Cordeiro, Vincent Lagente, Marco A Martins, Patrícia MR e Silva
2005 Memórias do Instituto Oswaldo Cruz  
The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other. This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the
more » ... nsequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.
doi:10.1590/s0074-02762005000900021 pmid:15962110 fatcat:4zvvczy3wzbe7iolxpf7lztvmi