Inhibition of a Vesicular Stomatitis Virus Mutant by Rifampin

Marie-Claude Moreau
1974 Journal of Virology  
Rifampin reversibly inhibits the intracellular replication of a VSV mutant, whereas a revertant variant selected from this viral population, as well as the wild strain, are not affected by this drug. Rifampin inhibits transcriptase activity of the sensitive mutant only and, consequently, total viral RNA synthesis decreases significantly in the cells.
doi:10.1128/jvi.14.3.517-521.1974 fatcat:3c3ipkxbjvdg5e3oabxuuupcbi