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Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives
Biological and Pharmaceutical Bulletin
In this study we describe the design, synthesis, and antibacterial activity of novel pleuromutilin analogs. A series of new compounds containing piperazine and alkylamino or arylamino groups was synthesized. The new compounds were characterized via 1 H-NMR, 13 C-NMR, Fourier transform (FT)-IR and MS, and were further evaluated for their in vitro activity against seven Gram-positive, and one Gram-negative, pathogens. Antibacterial data revealed that all compounds exhibited moderate to gooddoi:10.1248/bpb.b15-00123 pmid:26133714 fatcat:p3xgono2rbb2he7g22npmm4zvm