Total synthesis of (−)-petrosiol E

Linlin Wang, Xing Zhang, Jun Liu, Yuguo Du
2014 Tetrahedron  
(À)-Petrosiol E, a metabolite of sponge Petrosia strongylata, has been synthesized in 32% overall yield from cheap natural D-xylose in 10 steps. Our strategy provides an efficient way for the total synthesis of other petrosiol members, featuring the three contiguous stereogenic centers are easily constructed from D-xylose chiral template.
doi:10.1016/j.tet.2014.09.030 fatcat:nqgw2naxpresxfhaeafs2fkdgq