TRANSPATH(R): an information resource for storing and visualizing signaling pathways and their pathological aberrations

M. Krull
2006 Nucleic Acids Research  
TRANSPATH â is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating
more » ... ween reactions that are evidenced by individual publications, generalizations of these reactions to construct speciesindependent 'reference pathways' and the 'semantic projections' of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilderÔ. The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH Ò and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH Ò Public 6.0 is freely accessible for users from non-profit organizations under http:// www.gene-regulation.com/pub/databases.html.
doi:10.1093/nar/gkj107 pmid:16381929 pmcid:PMC1347469 fatcat:nsibv3dy6vfcniy2okxfpcfsge