Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

Zafer Ömer Özdemir, Murat Şentürk, Deniz Ekinci
2011 Journal of Enzyme Inhibition and Medicinal Chemistry  
Here we determined the in vitro inhibitory effects of 5-(2-hydroxyethyl)-3,4-dimethylthiazolium iodide (1), 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride (2) and thiamine (3) on human erythrocyte carbonic anhydrase I, II isozymes (hCA I and hCA II) and secreted isoenzyme CA VI. K I values ranged from 0.38 to 2.27 µM for hCA I, 0.085 to 0.784 µM for hCA II and 0.062 to 0.593 µM for hCA VI, respectively. The compounds displayed relatively strong actions on hCA II, in the same range as
more » ... e clinically used sulfonamidesethoxzolamide, zonisamide and acetazolamide.
doi:10.3109/14756366.2011.637200 pmid:22145674 fatcat:hffmscvqorhmdayih7s6f6cnhi