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and Objectives Cytotoxic T lymphocytes (CTL) may use two effector mechanisms to kill their target cells: perforin (PFN) and granzyme B (GrB)-dependent granule-mediated cell death and death receptor-mediated cell death. Controversy exists whether, in addition to PFN/GrB-mediated apoptosis, death receptor-induced apoptosis contributes to the elimination of human tumor cells by CTL. Design and Methods Since the two CTL-mediated effector mechanisms differ in time required to eliminate target cells,doi:10.3324/haematol.11308 pmid:18055991 fatcat:6hlcqsveqng6xkjtiho3wtkjqq