The Biomedical Engineering Group of the University of Seville (GIB) is developing new strategies to apply the home health care paradigm within End Stage Renal Disease (ESRD) Patients. In this paper we first review the current status of ESRD patients in Spain, Europe and USA. In the second part, the formal definition of the novel Virtual Center for Renal Support (VCRS) is done. Design of VCRS relies on a modelbased system analysis methodology. The knowledge-based assistance to be provided by

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... is carried on the Patient Physiological Image Component (PPI Component). This is a computing component based on cutting-edge Modelling & Simulation Technology, which gives the physician the ability to predict clinical events, infer technical and physiological problems, compute no previously measured variables and is also an aid for diagnosis, prescription and supervision of therapies.