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A Secreted BMP Inhibitor Mediates Metastatic Colonization in the Lung
2012
Cancer Discovery
Preserved Fulltext
Major finding: Coco promotes reactivation and metastatic outgrowth of dormant breast cancer cells in the lung. Mechanism: Coco counteracts BMP signaling to enhance the self-renewal of metastasis-initiating cells. Impact: The Coco gene expression signature may help predict breast cancer relapse to the lung.
doi:10.1158/2159-8290.cd-rw2012-137
fatcat:3gdwsq5hubha3lwefbmaqyznw4