A Secreted BMP Inhibitor Mediates Metastatic Colonization in the Lung

2012 Cancer Discovery  
Major finding: Coco promotes reactivation and metastatic outgrowth of dormant breast cancer cells in the lung. Mechanism: Coco counteracts BMP signaling to enhance the self-renewal of metastasis-initiating cells. Impact: The Coco gene expression signature may help predict breast cancer relapse to the lung.
doi:10.1158/2159-8290.cd-rw2012-137 fatcat:3gdwsq5hubha3lwefbmaqyznw4