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Protein Folding in High-Dimensional Spaces: Hypergutters and the Role of Nonnative Interactions
2005
Biophysical Journal
We explore the consequences of very high dimensionality in the dynamical landscape of protein folding. Consideration of both typical range of stabilizing interactions, and folding rates themselves, leads to a model of the energy hypersurface that is characterized by the structure of diffusive "hypergutters" as well as the familiar "funnels". Several general predictions result: 1), intermediate subspaces of configurations will always be visited; 2), specific but nonnative interactions may be
doi:10.1529/biophysj.103.036616
pmid:15501939
pmcid:PMC1304996
fatcat:ppkhibxjarbvhh75j6uxfdclei