The effect of propylene glycol and glycerol on carbohydrate and lipid metabolism in rabbits - short communication

Robert Kupczyński, Department of Environmental Hygiene and Animal Welfare, Faculty of Biology and Animal Science, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland, Michał Bednarski, Michał Bednarski
2020 Veterinarski arhiv (Tisak)  
_____________________________________________________________________________ KuPczyńsKi, R., M. BednaRsKi, T. PiasecKi: The effect of propylene glycol and glycerol on carbohydrate and lipid metabolism in rabbits -short communication. Vet. arhiv 90, 307-316, 2020. aBsTRacT This study examined the effects of glycogenic precursors (propylene glycol and glycerol) on lipid and carbohydrate metabolism of rabbit does fed a restricted diet. The study included 48 females of the Hyplus genetic line,
more » ... s genetic line, divided into primiparous and multiparous groups. On the 4 th day of the restricted diet, the rabbits were orally administered propylene glycol (PG) or glycerol (G), 2 mL/kg body weight 0.75 . Blood samples were collected immediately prior to administration of the glycogenic precursors and 30, 60, 90, 180, and 360 minutes thereafter. Serum concentrations of glucose, non-esterified fatty acids (NEFA), and β-hydroxybutyric acid were determined. Following the use of both glycogenic precursors, glucose concentration increased after 30 min., which was maintained until the end of the experiment. A significant (P<0.01) decrease in NEFA occurred 120 min after PG was given to primiparous and multiparous does, and remained low up to 360 min after administration. For glycerol, the decrease in NEFA occurred later after 360 min. The mean glucose concentration for the whole period was lower in multiparous females, and higher in primiparous ones. We revealed that both propylene glycol and glycerol showed the evident effect of lipolysis inhibition and gluconeogenesis stimulation, which can be used in practice (e.g. lactation, reproduction).
doi:10.24099/vet.arhiv.0623 fatcat:qkqhriqi5jcfnkkhhwxbr6ut2q