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Knee pain is a leading cause of disability and the most prevalent form in the world. It is associated with tissue inflammation, physical disability and imbalanced homeostasis in cartilage. As the number of people with age greater than 35 years increases, so does the prevalence of knee pain and the need for cost effective treatment and care. A treatment strategy is needed which takes into account the underlying physiology of degenerative joint disease, but it should also consider the differentdoi:10.7860/jcdr/2018/31013.11244 fatcat:4xni45mkmnbcdo5vsa6k7xohr4