Encoding information in quantum systems can offer surprising advantages but at the same time there are limitations that arise from the fact that measuring an observable may disturb the state of the quantum system. In our work, we provide an in-depth analysis of a simple question: What happens when we perform two measurements sequentially on the same quantum system? This question touches upon some fundamental properties of quantum mechanics, namely the uncertainty principle and the

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... y of quantum measurements. Our results have interesting consequences, for example they can provide a simple proof of the optimal quantum strategy in the famous Clauser-Horne-Shimony-Holt game. Moreover, we show that the way information is encoded in quantum systems can provide a different perspective in understanding other fundamental aspects of quantum information, like non-locality and quantum cryptography. We prove some strong equivalences between these notions and provide a number of applications in all areas.