Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease

J Mehta, P Mehta
1982 Circulation  
Suppression of platelet function is thought to be a mechanism of propranolol's beneficial action in angina pectoris. To study the effects of propranolol on platelets, we measured plasma ,8 thromboglobulin and plasma thromboxane B2 (TXB2, stable metabolite of TXA2) levels by radioimmunoassay as indexes of platelet a-granule and TXA2 release, respectively. Platelet TXA2 generation in vitro in response to arachidonate and thrombin was also quantitated. Twenty-nine patients with coronary disease 15
more » ... coronary disease 15 not taking propranolol (group A) and 14 taking propranolol (group B) and 15 normal subjects were studied. Plasma 1-thromboglobulin levels were increased in group A and B patients (mean 63 ± 8 and 96 + 14 ng/ ml, respectively) compared with normal subjects (mean 46 ± 6 ng/ml). Plasma TXB2 levels were similar in group A and B patients and in normal subjects (mean 148 ± 41, 149 36 and 216 ± 39 pg/ml). Arachidonate-induced platelet TXA2 generation was significantly higher in group A patients than in normal subjects (725 ± 393 vs 82 ± 25 pg TXB2/108 platelets, p < 0.001). In contrast, platelets from group B patients h-ad very low TXA2 generation (mean 21 ± 18 pg) compared with platelets from group A patients or normal subjects (p < 0.001). Similar results were obtained using thrombin. These data show that propranolol therapy does not affect platelet-released ,/3 thromboglobulin or TXA2 at rest, but significantly reduces the capability of platelets to generate TXA in vitro. Reduction in platelet TXA2 generation may be an important mechanism of action of propranolol in patients with coronary artery disease.
doi:10.1161/01.cir.66.6.1294 pmid:6216027 fatcat:5bbrgg57nrbbvgcmkpjvllsluu