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Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease
1982
Circulation
Suppression of platelet function is thought to be a mechanism of propranolol's beneficial action in angina pectoris. To study the effects of propranolol on platelets, we measured plasma ,8 thromboglobulin and plasma thromboxane B2 (TXB2, stable metabolite of TXA2) levels by radioimmunoassay as indexes of platelet a-granule and TXA2 release, respectively. Platelet TXA2 generation in vitro in response to arachidonate and thrombin was also quantitated. Twenty-nine patients with coronary disease 15
doi:10.1161/01.cir.66.6.1294
pmid:6216027
fatcat:5bbrgg57nrbbvgcmkpjvllsluu