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Mathematical modelling and computational analysis play an essential role in improving our capability to elucidate the functions and characteristics of complex biological systems such as metabolic, regulatory and cell signalling pathways. The modelling and concomitant simulation render it possible to predict the cellular behaviour of systems under various genetically and/or environmentally perturbed conditions. This motivates systems biologists/bioengineers/bioinformaticians to develop new toolsdoi:10.1093/bib/bbn039 pmid:18805901 pmcid:PMC2638623 fatcat:hf6nu6opujdnjlt6ti3r7z3ny4