Diffusion imaging in humans at 7T using readout-segmented EPI and GRAPPA

Robin M. Heidemann, David A. Porter, Alfred Anwander, Thorsten Feiweier, Keith Heberlein, Thomas R. Knösche, Robert Turner
2010 Magnetic Resonance in Medicine  
The Anatomical magnetic resonance imaging studies at 7T have demonstrated the ability to provide high quality images of human tissue in vivo. However, diffusion-weighted imaging at 7T is limited by the increased level of artifact associated with standard, single-shot, echoplanar imaging (EPI), even when parallel imaging techniques such as GRAPPA are used to reduce the effective echo spacing. Readout-segmented EPI in conjunction with parallel imaging has the potential to reduce these artifacts
more » ... allowing a further reduction in effective echo spacing during the EPI readout. This study demonstrates that this approach does indeed provide a substantial improvement in image quality by reducing image blurring and susceptibility-based distortions, as well as by allowing the acquisition of diffusion-weighted images with a high spatial resolution. A preliminary application of the technique to high resolution diffusion tensor imaging (DTI) provided a high level of neuroanatomical detail, which should prove valuable in a wide range of applications.
doi:10.1002/mrm.22480 pmid:20577977 fatcat:aro3akwzwrcvjgubcsn2f73lou