Role of ETS Family Transcription Factors in Vascular Development and Angiogenesis
Cell Structure and Function
The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family
... ion factors in vascular development and angiogenesis. Key words: vasculogenesis/angiogenesis/transcription factor/ETS The vascular endothelium is a continuous monolayer of endothelial cells (ECs) lining the luminal surface of blood vessels. ECs are normally quiescent, but they have the ability to proliferate and form neo-vessels. Angiogenesis is the formation of neo-vessels from pre-existing blood vessels. It occurs in a wide range of physiological and pathological states, including embryogenesis, wound healing, diabetic retinopathy, rheumatoid arthritis, and growth of solid tumors. Organ formation requires precise spatial and temporal coordination in the expression of multiple genes in individual cells. Transcription factors determine gene expression by binding to the specific DNA sequences within the promoter/ enhancer regions of genes and allowing transcriptional activation or repression of genes. Therefore, transcription factors play fundamental roles in gene activity during vascular development and angiogenesis.