A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf
.
Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal
2019
PLoS Genetics
Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated negative factors produced by muscle drive neurodegeneration in Schwann cell-deficient mice. We find that thrombin, the hepatic serine protease central to the hemostatic coagulation cascade, is one such negative factor. Trancriptomic analysis shows
doi:10.1371/journal.pgen.1007948
pmid:30870413
pmcid:PMC6417855
fatcat:jfadv7riyvddbfivhsjbuqqhfi