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Faculty of 1000 evaluation for CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4(+) T helper 1 cell differentiation
[dataset]
2012
F1000 - Post-publication peer review of the biomedical literature
unpublished
Differentiation of naïve CD4 + T cells into T helper (T h ) cells is a defining event in adaptive immunity. The cytokines and transcription factors that control Th cell differentiation are understood, however it is not known how this process is orchestrated within lymph nodes (LNs). Here we have shown that the CXCR3 chemokine receptor was required for optimal generation of interferon (IFN)-γ secreting Th1 cells in vivo. Using a CXCR3 ligand reporter mouse, we found that stromal cells
doi:10.3410/f.717963933.793465692
fatcat:tstjgquahzfnbcnjzokrqrmspm