Toxicological Assessment of Aqueous Extracts of Leaves and Seeds of Moringa oleifera on the Blood Biochemical Profile of Rats

Madiha Ilyas, M. Umair Arshad, Shahzad M.A. Basra, Abida Kausar, Faraz Ali Rana, Ayesha Riaz
2016 International Journal of Agriculture and Biology  
To cite this paper: Ilyas, M., M.U. Arshad, S.M.A. Basra, A. Kausar, F.A. Rana and A. Riaz, 2016. Toxicological assessment of aqueous extracts of leaves and seeds of Moringa oleifera on the blood biochemical profile of rats. Abstract Moringa is a known medicinal plant utilized for the food supplementation and treatment of various diseases. A study was conducted to evaluate the toxicity of moringa leaf extract (MLE) and moringa seed extract (MSE). For the purpose, male Sprague-Dawley rats were
more » ... -Dawley rats were used and both MLE and MSE up to 2200 mg/kg were orally administered in an acute toxicity trial of the extracts. A sub-acute toxicity trial was also done by daily administration of the extracts at 600, 1000 and1800 mg/kg body weight orally for 21 days and distilled water was given to the control group. In acute toxicity test, moringa extracts caused no death in animals even at 2200 mg/kg dose. In sub-acute toxicity study non-significant differences were observed in all the haematological and biochemical parameters at all doses of MLE and MSE in rats group compared to the control. Moreover, food intake of all the treated rats was reduced compared with the control and significant changes were observed in the body weight of the rats. Hence, the study concluded that both moringa leaf and seed extracts were safe for remedial purpose and can safely be used for human and animal feed purpose.
doi:10.17957/ijab/15.0248 fatcat:sect6rp2k5fopgzau6h6prrhhm