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Serum heated at 56" in amounts of 0.2 C.C. The same results were obtained when horse serum and the serum of a rabbit immunized thereto were used as antigen and antibody. Hence we may conclude that complement plays no role in the anaphylactic reaction. Inasmuch as complement is essential to the production of anaphylatoxin, this is equivalent to saying that anaphylatoxin plays no r61e in anaphylaxis. (1088)doi:10.3181/00379727-13-25 fatcat:hvxrsnbfo5g6dk56qlzyznn7mq