Follicle Online: an integrated database of follicle assembly, development and ovulation

J. Hua, B. Xu, Y. Yang, R. Ban, F. Iqbal, H. J. Cooke, Y. Zhang, Q. Shi
2015 Database: The Journal of Biological Databases and Curation  
These authors contributed equally to this work. Citation details: Hua,J., Xu,B., Yang,Y., et al. Follicle online: an integrated database of follicle assembly, development and ovulation. Abstract Folliculogenesis is an important part of ovarian function as it provides the oocytes for female reproductive life. Characterizing genes/proteins involved in folliculogenesis is fundamental for understanding the mechanisms associated with this biological function and to cure the diseases associated with
more » ... olliculogenesis. A large number of genes/proteins associated with folliculogenesis have been identified from different species. However, no dedicated public resource is currently available for folliculogenesis-related genes/proteins that are validated by experiments. Here, we are reporting a database 'Follicle Online' that provides the experimentally validated gene/protein map of the folliculogenesis in a number of species. Follicle Online is a web-based database system for storing and retrieving folliculogenesis-related experimental data. It provides detailed information for 580 genes/proteins (from 23 model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Mesocricetus auratus, Bos Taurus, Drosophila and Xenopus laevis) that have been reported to be involved in folliculogenesis, POF (premature ovarian failure) and PCOS (polycystic ovary syndrome). The literature was manually curated from more than 43 000 published articles (till 1 March 2014). The Follicle Online database is implemented in PHP þ MySQL þ JavaScript and this user-friendly web application provides access to the stored data. In summary, we have developed a centralized V C The Author(s) Figure 3. Screen shots of user interface-result page. Collage of some of the results produced via clicking the 'Browse' button in both 'Simple' and 'Advanced' search options.
doi:10.1093/database/bav036 pmid:25931457 pmcid:PMC4414955 fatcat:xcvdtsp6kjhohb25l7dltxzzee